- 期刊
- OpenAccess
Effects of Anabasine, a Tobacco Smoke Constituent, on Alcohol Consumption in Female Alcohol Preferring (P) Rats
並列摘要
In addition to nicotine, there are a variety of other psychoactive compounds in tobacco smoke. Little is known about the interaction of these tobacco constituents on alcohol intake. In this study, we examined one of these constituents, anabasine, which acts on nicotinic receptors, for its effects on alcohol intake and preference in alcohol preferring (P) rats. Adult female P rats were allowed continuous 3-bottle access to drink 0%, 10% or 15% alcohol for over 6 weeks. After establishment of a stable baseline for alcohol intake, rats were injected acutely with 0.02, 0.2 or 2.0mg/kg anabasine or saline. Alcohol and water intake were measured at 2, 4, 6, and 24 h after each treatment. Pretreatment with anabasine at 2mg/kg significantly reduced alcohol intake during the 0-2 h and decreased alcohol preference during 2-4 h and 6-24 h periods but increased water intake during the 2-4 h period. Other doses of anabasine did not exert significant effects on alcohol or water intake. These results suggest that anabasine may influence alcohol intake presumably by interacting with neuronal nicotinic receptors.
延伸閱讀
- Badamasi, M., & Esomonu, U. (2012). Accessing the Effect of Cigarette Smoke Exposure on Spatial Memory in Wistar Rats. Asian Journal of Medical Sciences, 4(3), 117-120. https://www.airitilibrary.com/Article/Detail?DocID=20408773-201206-201510290014-201510290014-117-120
- 張齡尹、李蘭、張新儀（2008）。Relationship between Aggressive Behavior and Initiation of Tobacco and Alcohol Use among Students。台灣公共衛生雜誌，27(6)，530-542。https://doi.org/10.6288/TJPH2008-27-06-07
- Kalejaiye, O., Getachew, B., Ferguson, C. L., Taylor, R. E., & Tizabi, Y. (2017). Alcohol-Induced Increases in Inflammatory Cytokines Are Attenuated by Nicotine in Region-Selective Manner in Male Rats. Journal of Drug and Alcohol Research, (6), 1-6-007. https://doi.org/10.4303/jdar/236036
- 謝淑卿、尹祚芊（1996）。A Study of Conflicts between Tobacco Smoking Perception and Behavior among Adults。護理研究，4(3)，219-230。https://doi.org/10.7081/NR.199609.0219
- Jaakkola, M. S., & Jaakkola, J. J. (2002). Effects of Environmental Tobacco Smoke on the Respiratory Health of Adults. Scandinavian Journal of Work, Environment & Health, 28(suppl 2), 52-70. https://www.airitilibrary.com/Article/Detail?DocID=03553140-200212-201011100037-201011100037-52-70