Fat embolism syndrome (FES) is a well-known complication of long bone fractures caused by the lipid droplets in the blood circulation which block the small vessels. FES typically features pulmonary symptoms, neurological abnormalities, and petechial rashes. The incomplete form of FES such as cerebral fat embolism (CFE) without a pulmonary or dermatological manifestation is diagnostically challenging. Most patients with CFE can fully recover without a neurologic deficit after supportive treatment within a few weeks or months. Early diagnosis and treatment can improve the prognosis of patients with this condition and prevent the development of complications. Neuroimaging, especially magnetic resonance imaging, is the main diagnostic tool. Herein, we report a rare and unusual case of CFE that led to significant neurogenic deficits in a male patient.