- 期刊
由白藜蘆醇調控細胞週期探討多酚物質的防癌效果
Regulatory Checkpoints of Cell Cycle by Resveratrol to Anti-cancer Activities of Natural Polyphenols
摘要
當細胞增生並忽略抑制生長與細胞凋亡的訊息，將使細胞無限制的分裂增生走向癌化，而尋找具細胞週期調控能力的化合物已成為抗癌的基本策略之一。白藜蘆醇是多酚類之植物二次代謝物，主要存於葡萄科、蓼科與豆科植物等，也存於虎杖、落花生根等多種常見中藥材中。目前已知在腫瘤形成的過程中，白藜蘆醇在不同細胞株中皆顯示許多抗癌潛力活性：（A）抑制增生與分化；（B）使細胞週期停留於S期；（C）抑制CDK7和p34Cdc2激酶使細胞停滯於S 與G2/M期；（D）少部分的癌細胞會停留於S/G2期；（E）誘導細胞凋亡，（F）抗血管新生、抗癌轉移與癌細胞入侵的能力。本篇論文將白藜蘆醇對細胞週期調控的角度，探討天然多酚類化合物在潛力抗癌藥物開發及應用上可能的方向與機制。
並列摘要
During carcinogensis, cellular growth is altered by over-signals and insensitivity to the antigrowth signals and evasion of apoptosis. Finally, cells will limitless replication and metastasis. Regulation of the cell cycle by a chemical compound would be a new therapy strategy. Resveratrol also is a polyphenol compound and describes antioxidant and anti-carcinogenic effects. Variety of cancer cells can inhibit growth by resveratrol and a lot research indicate that resveratrol could inhibit the proliferation, stop cancer cells at the S phase of the cell cycle, arrest the cell cycle at the S-phase as well as at the G2/M-phase inhibiting Cdk7 and p34Cdc2 kinases, arrest cancer cells at the S/G2 phase of the cell cycle, induces apoptosis, inhibit angiogenesis, metastasis and tissue invasion. This review outlined cell cycle regulators available for resveratrol and reason for new possible anti-cancer targets and the anti-proliferative of resveratrol.