文獻回顧：致病微生物失活之光動力療法

Mini-Review: Photodynamic Therapy on Inactivation of Pathogenic Microbial

楊明曄(Ming-Yeh Yang) ； 胡安仁(Anren Hu) ； 陳良宇(Liang-Yu Chen)

《MC-Transaction on Biotechnology》 5卷1期 (2013/03) Pp. 30-40

摘要

以光動力療法的光化學特質為基礎，探討光對致病性微生物失活的影響。光照可造成光敏劑分子的降解或催化產生活性氧分子。短波長的紫外光及藍光對微生物具有失活的能力，但短波長的光波具有高能量，可能導致生物細胞暴露於危險中。選擇合適的光敏劑，在長波長的藍色可見光照射下，在特定的光通量及劑量下，即能對致病微生物產生失活作用，將是一項簡單且安全的醫療衛生技術。

關鍵字

光敏劑 ； 光動力療法 ； 藍光 ； 微生物失活

並列摘要

Based on the photochemical properties of photodynamic therapy, the light-induced inactivation of pathogenic microbial was investigated. The photosensitizer with light can trigger or catalyze to degrade the chemical molecules and to generate the reactive oxygen species (ROS). The UV and blue light could make microbial inactivate, but the short wavelength lights with higher energy may cause cells exposed to danger. By appropriate photosensitizer, the irradiation of visible blue lights with longer wavelength, that also product the inactivation of pathogenic microbial under the specific conditions. The photodynamic therapy with blue light and photosensitizer will be a simple and safe technique on biomedical fields.

並列關鍵字

photosensitizer ； photodynamic therapy ； blue light ； microbial inactivation