骨骼肌是調節免疫反應的主要關鍵

Skeletal Muscle is a Major Key to Regulate Immune Response

呂啓誠(Chi-Cheng Lu) ； 方世華(Shih-Hua Fang)

《國立臺灣體育運動大學學報》 10卷1期 (2021/01) Pp. 1-19

https://doi.org/10.3966/2226535X2021011001001

摘要

運動係藉由骨骼肌之收縮而完成身體所有的活動，同時骨骼肌有如內分泌器官，可以產生許多種類肌細胞激素。許多肌細胞激素能促進免疫細胞增生及增加細胞吸附分子之表現，進而促使更多的免疫細胞移動，達到免疫系統之活化。介白素-6最早被發現，也是最重要的肌細胞激素之一，可抑制促發炎細胞激素的作用，因而具抗發炎之功效，有助於預防或治療因長期慢性發炎所導致的心血管疾病及代謝症候群。透過運動所誘發產生的肌細胞激素可負責骨骼肌、免疫系統與其他器官組織之間的對話，維持生理之恆定與健康。過去的研究發現，規律適度運動者比久坐者出現上呼吸道感染症狀的時間較短，而且嚴重程度也較輕。因此，藉由適度的運動，促使骨骼肌提升免疫功能乃是提升免疫力的最佳作法之一。

關鍵字

骨骼肌 ； 肌細胞激素 ； 免疫系統 ； 適度運動

並列摘要

Exercise refers to body activities through skeletal muscle contractions. Skeletal muscles produce various myokines like an endocrine organ, and many myokines promote the proliferation of immune cells while increasing the expression of cell adhesion molecules, thereby enhancing the movement of more immune cells and activating the immune system. Interleukin-6, the first identified important myokine, exhibits inhibition on the activities of pro-inflammatory cytokines that could prevent cardiovascular diseases and metabolic syndrome caused by long-term chronic inflammation. The myokines induced by exercise are also responsible for the cross-talk among skeletal muscle, the immune system and other tissues to maintain physiological stability and health. Past studies have reported that persons maintaining exercise habits experience shorter and less severe periods of upper respiratory tract infection. In conclusion, regular and moderate exercises enhance the regulatory activities of skeletal muscles on the immune system, and is one of the best ways to improve immunity.

並列關鍵字

Skeletal muscle ； myokines ； immune system ； moderate exercise

參考文獻

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