- 期刊
- OpenAccess
Clinicopathological Significance of Fatty Acid Synthase Expression in Pancreatic Ductal Carcinoma
並列摘要
Introduction: Fatty Acid Synthase (FAS) expression is increased in various cancers and it contributes to tumor cellular activities. In clinical practice, pancreatic ductal carcinoma is regarded as a cancer with poor prognosis. Aims: To investigated FAS expression in pancreatic ductal carcinoma (PDC) and compare with clinic-pathological features. Methods: ＂We studied 38 patients who had resection for PDC in our hospital. ＂We compared FAS staining with clinico-pathological features, including Ki-67 and P53 staining. Results: Using our criteria, out of 38 cases, 15 cases were considered FAS positive. FAS positivity correlated with Ki-67 positivity (p = 0.001), but there was no significant relationship between FAS expression and P53 staining (p = 0.224). FAS positive cases showed higher rate of lymph node metastases (p = 0.0038). FAS expression was related to differentiation of adenocarcinoma (p = 0.0347). Clinically, overall survival rate of FAS positive cases was lower than that of FAS negative cases (p = 0.0068). Conclusion: FAS expression may be related to lymph node metastases and clinical behavior in pancreatic ductal carcinoma.
延伸閱讀
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