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- OpenAccess
Reduction of Peritoneal Adhesion Bands by Mycophenolate Mofetil (CellCept) and Prednisolone in Rats
並列摘要
Aims: The purpose of this study was to assess the efficacy of prednisolone and CellCept in decreasing postoperative adhesion band formation in rats. Methods: Sixty male rats were randomly divided into three equal groups. A standard midline incision was made on the abdomen of each rat, then 2 mL of 10% sterile solution Talc was injected into intraperitoneal cavity in order to induce adhesion. Group 1 served as control group, while group 2 received oral CellCept (40 mg/kg/d) and group 3 received oral Prednisolone (5 mg/kg/d) for 4 weeks. Results: The formation of adhesion bands in control group was significantly higher than the prednisolone and CellCept group (p＜0.001). The amount of adhesion bands in the second group was similar to the third one. Conclusion: Orally administered CellCept is as effective as oral prednisolone in declining chance of intraperitoneal adhesion band formation, although it causes fewer complications such as infection in rats.
延伸閱讀
- Wei, L. L., Lin, Y. F., & Yong, T. K. (1996). The Ratio between Plasma Pyridoxal Phosphate and Pyridoxal Alteration in Azotemic Rats. 中華民國營養學會雜誌, 21(2), 111-120. https://doi.org/10.6691/JCNS.199605_21(2).0001
- Tsai, S. C., Kau, M. M., & Wang, P. S. (2019). Effects of Amphetamine on the Release of Corticosterone and Aldosterone in Rat Adrenocortical Cells. Adaptive Medicine, 11(4), 127-132. https://doi.org/10.4247/AM.2019.ABJ239
- 賴秋蓮、林瑞泰、劉景寬、戴志達、洪純隆（1995）。The Changes of Central and Peripheral Nerve Conduction and the Effect of Thyroxine Replacement in Thyroidectomized Rats。The Kaohsiung Journal of Medical Sciences，11(10)，589-598。https://doi.org/10.6452/KJMS.199510.0589
- Hei, Z. Q., Gan, X. L., Shen, N., Pang, H. Y., & Guan, J. Q. (2010). Effects of Propofol Intravenous Injection Bolus on the Left Ventricular Function and the Myocardial β-Adrenoceptor in Rats. The Chinese Journal of Physiology, 53(2), 99-104. https://doi.org/10.4077/CJP.2010.AMK089
- Pu, H. F., Yang, M. Y., Wang, S. W., Kao, Y. C., Jeng, F. S., & Wang, S. G. (1987). Effects of Thyroidectomy on the Metabolic Clearance Rate of Prolactin and Prolactin Release in the Rat. The Chinese Journal of Physiology, 30(1), 15-24. https://www.airitilibrary.com/Article/Detail?DocID=03044920-198706-30-1-15-24-a