We reported our nursing experience about caring two cases for Coronavirus disease 2019 (COVID-19) infected diseases patients, mainly focused on the mental health care. Patients admitted in the negative pressure isolation ward might having care needs in physical, mental, and social dimensions. According to our clinical observation and telephone interviews with patients, we suggested personalized nursing cares by listening, music relaxation, and emotional expression might be the suitable methods to lead patients to release their acute stress status.