Intracranial vertebral artery (VA) dissection is a life-threatening condition with varies clinical manifestations including headache, vertigo, neck pain, ataxia, visual or sensory deficit. However, reports regarding initial presentation of solely having hiccups followed by vertigo in patients with VA dissection remain sparse. We report a 66-year-old man diagnosed with left medullary infarction secondary to left VA dissection, initially presented with newly onset hiccups and followed by vertigo, with rapid progression to the symptoms compatible with Wallenberg syndrome within twelve hours. The result of brain magnetic resonance image demonstrated intramural hematoma and dissecting stenosis of left VA. The followed up computed tomography angiography in 10 days after symptom onset showed tapering end of left VA with partial flow restoration. Our report highlights that newly onset hiccups could be the first isolated symptom of VA dissection and rapid progression of clinical symptoms should be considered.