- 期刊
- OpenAccess
The Glucose Metabolism in Metabolic Syndrome Patients with Non- Alcoholic Fatty Liver Disease
並列摘要
Aim: To explore the association between NAFLD and MetS, and to clarify the difference of glucose metabolism between MetS with and without NAFLD. Methods: In this paper, we explore the association between NAFLD and MetS from the viewpoint of clinical characters and discuss the difference of abnormal glucose metabolism in the etiology of NAFLD and MetS, which based on metabolic profiling of urinary carbohydrates using gas chromatography/mass spectrometry (GC/MS) and multivariate statistical analysis with Model Population Analysis (MPA) based Support Vector Machines (SVMs). Results: The BMI, waist circumference, hip circumference, WHR and diastolic blood pressure in MetS patients with NAFLD were significantly higher than patients without NAFLD (P＜0.001 or P＜0.05). The incorporative obese and hyperlipidemia were significantly higher in MetS patients with NAFLD compared with those without NAFLD (P＜0.001 and P＜0.05). The biochemical analysis indicated that triglyceride and glycated hemoglobin were significantly higher in MetS patients with NAFLD (P＜0.05). Other significant differences were not found in fasting glucose, post-load glucose, HDL-C, ALT and VLDL-C between the two groups (P＞0.05). Consequently, two potential biomarkers, Glucose and Inositol A, were discovered in the two groups using MPA/SVM and kruskal-Wallis test. Conclusion: This research shows the incidence of abdominal obese and hyperlipidemia to be significantly higher in MetS patients with NAFLD than that observed in those without NAFLD. Moreover, the higher glycated hemoglobin in MetS patients with NAFLD suggests the poorer abnormal glucose metabolism. Furthermore, according the GC/MS combined with MPA/SVM, the two groups could be separated apparently from the glucose data, and two differential metabolites including Glucose and Inositol A are found.
延伸閱讀
- Dai, X., & Wang, B. M. (2015). Role of Gut Barrier Function in the Pathogenesis of Nonalcoholic Fatty Liver Disease. Gastroenterology Research and Practice, 2015(), 382-387-042. https://doi.org/10.1155/2015/287348
- 陳瑋成、楊宜青、吳晉祥、黃盈翔、張尹凡、盧豐華、張智仁（2012）。The Correlates of Nonalcoholic Fatty Liver Disease in Subjects with Normal Liver Function。台灣家庭醫學雜誌，22(1)，25-33。https://doi.org/10.7023/TJFM.201203.0025
- Li, J., Cordero, P., Nguyen, V., & Oben, J. A. (2016). The Role of Vitamins in the Pathogenesis of Non-alcoholic Fatty Liver Disease. Integrative Medicine Insights, (2016), 19-25. https://doi.org/10.4137/IMI.S31451
- Kumar, M. S., Singh, A., Jaryal, A. K., Ranjan, P., Deepak, K. K., Sharma, S., Lakshmy, R., Pandey, R. M., & Vikram, N. K. (2016). Cardiovascular Autonomic Dysfunction in Patients of Nonalcoholic Fatty Liver Disease. International Journal of Hepatology, 2016(), 43-50. https://doi.org/10.1155/2016/5160754
- 張育霖、陳進生（2023）。Association of Metabolic Associated Fatty Liver Disease and Nonalcoholic Fatty Liver Disease with COVID-19。內科學誌，34(1)，32-38。https://doi.org/10.6314/JIMT.202302_34(1).06