In this research, a thermoelectric power generation device was developed and verified in the hot spring field. Since the hot spring field usually has cold water that can be obtained naturally from mountainous areas, it is inherently very suitable for the operation. Based on the nature of thermoelectric technology, this system is modularized. The system connects with cooling pipes. The system was divided into 6 sub-system units, which were connected in series and parallel to output wires. Due to the fluctuations in the supply of hot spring water, the system couldn't maintain the highest power generation stably for a long time. The results showed that the maximum power capacity of the system was 1.59kW when hot spring water temperature and cold water temperature were 124.3°C and 20.1°C relatively.