The study aimed at investigating lower leg compressed wear to lower limb muscle activation under different running speed. Eight young male with exercise habit were enrolled in the study. The lower limb muscle activation(Vastus medialis, Vastus lateralis , Rectus femoris, Biceps femoris, Tibialis anterior, Gastrocnemius) and vibration level (Tibialis anterior, Rectus femoris, Gastrocnemius) induced by three tie methods(without compression、20% compression、25% and 15-20% progressive compression) under four running speeds (7、9、11、13 KPH) were investigated by electromyography and accelerometer. The two-way ANOVA was applied for statistical measurement with a significant level of α=.05. No significant difference was found in muscle activation and muscle vibration by running under four speeds with three different tie methods. compression wears could not attenuate muscle activation, as well as muscle vibration.