Bilateral Reactive Pleural Effusion as a Complication of Picibanil Pleurodesis

使用Picibanil進行肋膜沾黏後造成雙側反應性肋膜積液

黃彥閔(Yen-Min Huang) ； 王正旭(Cheng-Hsu Wang) ； 于鍾傑(Chung-Chieh Yu) ； 張沛泓(Pei-Hung Chang) ； 黃仁聖(Jen-Seng Huang)

《台灣癌症醫學雜誌》 27卷6期 (2011/12) Pp. 268-275

https://doi.org/10.6323/JoCRP.2011.27.6.5

摘要

OK-432（picibanil）為一可激發免疫反應的藥物，目前已被證實可用於許多惡性腫瘤、腹水、及肋膜積水的治療。我們報告一停經後乳癌女性患者，以反覆右側惡性肋膜積水為表現，經OK-432肋膜沾黏治療後，發生雙側肋膜積水併呼吸困難。雙側肋膜積水經雙側引流後改善，於後續4個月內未再發生肋膜積水。我們藉由此案例報告此罕見的併發症並進行文獻回顧。

關鍵字

OK-432 ； picibanil ； 肋膜積水 ； 肋膜沾黏術

並列摘要

OK-432 (picibanil) is a potent immunostimulant which has demonstrated benefit in the treatment of several types of malignancies, malignant ascites, and pleural effusion. We report a female patient with premenopausal breast cancer presenting with refractory malignant right pleural effusion. Shortly after OK-432 pleurodesis, bilateral reactive pleural effusion developed, soon followed by dyspnea. The pleural effusion was improved by bilateral pigtail catheter replacement, and no more massive pleural effusion was noted in the following 4 months. This complication was possibly related to immune response, but further experience and investigation is needed to prove it.

並列關鍵字

OK-432 ； picibanil ； pleural effusion ； pleurodesis