Dramatic Antitumor Effect of Megestrol Acetate in a Metastatic Breast Cancer Premenopausal Patient During Hospice Care

Megestrol Acetate在一位接受安寧治療的停經前轉移乳癌患者有大幅抗癌效果

陳國興(Kuo-Hsing Chen) ； 林璟宏(Ching-Hung Lin)

《台灣癌症醫學雜誌》 29卷2期 (2013/06) Pp. 84-88

https://doi.org/10.6323/JoCRP.2013.29.2.4

摘要

荷爾蒙治療是荷爾蒙受體陽性乳癌的主要治療方式，Megestrol acetate，一種合成的黃體素，是一種轉移性乳癌和和子宮內膜癌的荷爾蒙治療，也是一個針對食慾缺乏症和惡病質的重要治療藥物。我們發表一位罹患荷爾蒙陽性之乳癌併肝轉移的四十歲女性，她因為之前術後輔助治療的不良經驗和重度憂鬱而拒絕任何抗癌藥物治療，但是她的乳癌卻在她因為食慾缺乏症及體重減輕時服用Megestrol acetate之後大幅緩解，而且持續兩年。我們提醒Megestrol acetate仍是一種重要的荷爾蒙治療，特別是在有食慾缺乏症和惡病質的病人。

關鍵字

乳癌 ； megestrol acetate ； 停經前

並列摘要

Hormone manipulation is the main therapy for hormone receptor positive breast cancers. Megestrol acetate, a synthetic progesterone derivative, is a hormone therapy for metastatic breast and endometrial cancers and also an important palliative treatment for cancer-related anorexia and cachexia. We report a dramatic response to megestrol acetate in a 40-year-old woman with extensive liver metastasis from hormone receptor-positive breast cancer. She refused any antitumor treatment for metastatic disease because of major depression and poor experience with prior adjuvant chemotherapy. She was admitted to hospice ward and received megestrol acetate for anorexia and unintentional weight loss. Unexpectedly, her tumors regressed considerably and she lived for 2 more years. Megestrol acetate remains an important hormone therapy for metastatic breast cancer, especially in patients with anorexia and cachexia.

並列關鍵字

breast cancer ； megestrol acetate ； premenopausal