急性缺血性腦中風的藥物治療及預防趨勢

Trends in the Medication Treatment and Prevention of Acute Ischemic Stroke

謝榛櫻(Chen-Ying Hsieh) ； 陳鳳櫻(Fong-Ying Chen) ； 林麗味(Li-Wei Lin) ； 王守玉(Shou-Yu Wang) ； 趙玉環(Yu-Huan Chao)

《醫院雙月刊》 48卷2期 (2015/04) Pp. 24-33

摘要

許多國家致力於急性缺血性腦中風的治療及預防，目前共識在急性期以恢復腦組織血液灌流為治療目標；預防復發的重點以抗血小板製劑、抗凝血劑為策略，臨床人員熟知缺血性腦中風治療趨勢有助於臨床照護。新型血栓溶解劑、抗凝劑及血管內介入治療已有多篇研究探討，本文以文獻探討瞭解缺血性腦中風的藥物治療趨勢，包括血栓溶解劑的使用時機、預防復發的藥物以及侵入性治療，比較相關研究成效、安全性、風險，提供臨床治療之參考。

關鍵字

急性缺血性腦中風 ； 血栓溶解劑 ； 抗血小板製劑 ； 抗凝血劑 ； 侵入性治療

並列摘要

Many researchers in different countries devote themselves to the treatment and prevention of acute ischemic stroke. Moreover, the goal of current treatment consensus in the initial phase of acute ischemic stroke is to restore blood perfusion of brain tissues. Furthermore, in order to prevent relapse of acute ischemic stroke, antiplatelet agents and anticoagulants are main strategies for long term management. There are many literature and research discussions concerning the current trend of ischemic stroke treatment, including new generation of thrombolytic agents, anticoagulant agent, and the vascular intervention. It is necessary for health care professionals to be familiar with the treatment trend regarding acute ischemic stroke in order to take care of the patients. In this article, we discuss the current tendencies in treatment of acute ischemic stroke which include the timing of thrombolytic agents' administration, use of medication or invasive method in prevention of relapse, and comparison of efficacy, risk and safety in related research. Through the discussion, it is able to offer as references for clinical treatment in the future.

並列關鍵字

acute ischemic stroke ； thrombolytic agents ； antiplatelet agents ； anticoagulants agent ； invasive treatment