口服玫瑰純露之大鼠急性毒性評估

玫瑰純露又稱為玫瑰花水，係以水蒸氣蒸餾法萃取玫瑰花瓣所得之產品，可作為香精、化妝品原料或飲料等多樣用途。為瞭解以健康安全的栽培方式，所生產出符合我國「食用花卉規範」的玫瑰花瓣原料所研製之玫瑰純露其食用之安全性，直接以水蒸氣蒸餾法萃取玫瑰花瓣所得之4：1（W/V）純露樣品，對大鼠進行口服急性毒性試驗，測試劑量為5 g/kg，投予後連續觀察14天。結果顯示，試驗期間全部鼠隻均無中毒症狀或死亡；在體重及增重方面，「玫瑰純露」處理組及對照組間並無顯著差異。血液學及血清生化學檢測結果，並未顯示有與試驗物質有關之影響。大鼠體內重要臟器，亦均無明顯因試驗物質引起之肉眼及組織病理變化。綜合試驗結果顯示，「玫瑰純露」對大鼠之口服急性毒性LD50值為大於5 g/kg，適量口服玫瑰純露，應無急性毒性副作用並具安全性。本項試驗研究，為我國臺灣地區首度以香藥草作物進行蒸餾萃取所得之純露產品為目標進行之急性毒性評估試驗，結果具有參考價值，並可供未來相關產品進行安全性評估之參考依據。

關鍵字

玫瑰純露；口服急性毒性； 50%致死劑量（LD50）

並列摘要

Rose Hydrosols is also called rose water, mainly comes from extracting rose petals by steam distillation, has been widely used in essence flavor, cosmetic and drink industry. This study was performed to assess the acute oral toxicity of rose hydrosols in Sprague Dawely (SD) rats. Rose hydrosols were single administrated orally with dosages of 5000 mg/kg body weight by feeding needle and then observed for 14 days. Mortality, signs of toxicity, mean body weights, mean body weights gains, and gross necropsy findings were recorded for 14 days post treatment of rose hydrosols. No animal death was found during the study period. In male and female rats, there were no statistical differences in the mean body weights and mean body weights gains between control and rose hydrosols groups. There were no rose hydrosols treatment-related findings in hematological, serum biochemical parameters, gross necropsy and histopathology evaluation. The results show that no acute adverse toxic affects of rose hydrosols for rats of either sex and the LD50 of feeding rose hydrosols in rats is over 5,000 mg/kg body weight. This is the first time that using hydrosol coming from herbs by steam distillation as the tested material for acute oral toxicity test in Taiwan, the results is valuable and could be considered when evaluating safety of the other hydrosol-related products.

並列關鍵字

rose hydrosols ； acute oral toxicity ； 50% lethal dosage

國際替代計量

口服玫瑰純露之大鼠急性毒性評估

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