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Mesenteric fibromatosis, or intra-abdominal desmoid tumor, is a rare proliferative disease affecting the mesentery that can pose a diagnostic and therapeutic challenge. It is a locally aggressive tumor that lacks metastatic potential but often recurs locally. Mesenteric fibromatosis with intestinal involvement can be easily confused with other primary gastrointestinal tumors, especially with that of the mesenchymal origin. We report a case of a 46-year-old male with no significant medical or surgical history, complaining of left side abdominal pain and fever for 3 days. The patient was thoroughly investigated and contrast-enhanced CT abdomen revealed a well-defined mass over the left upper abdomen near the splenic flexure. Exploratory laparotomy was underwent and a mass measuring 5.6 cm in diameter arising from the descending mesocolon was identified. Complete removal was accomplished with no need of small bowel or colon resection. Histopathological examination showed mesenteric fibromatosis. Postoperatively, patient was well and 3-month followup showed normal recovery.

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