Primary hepatic angiosarcoma (PHA) is an extremely rare neoplasm of liver with aggressive behavior and poor prognosis. PHA has variable and nonspecific clinical presentations and imaging features, which makes a great challenge in prompt and accurate diagnosis. We presented an uncommon case of a 57-year-old female with type 2 diabetes mellitus who presented with sepsis and a huge hepatic lesion mimicking pyogenic liver abscess on computer tomograph. The final diagnosis is PHA based on dynamic magnetic resonance imaging and histological diagnosis.