The grape is one of the important fruit in Taiwan. Twenty-five species of insect pests (15 families, 7 orders), 4 species of spider mites, 3 species of molluscas, 2 species of rodent and 4 species of birds have been listed as the pests of grape from the survey. The results showed that the seasonal occurrence of the major pests such as Zeuzera coffeae Nietner larvae appeared all year round with higher population density from June to July and from October to November, while as Notolophus australis posticus Walker from April to May, Euprotis taiwana (Shiraki), Theretra alecto L. and Anomala cupripes Hope from June to July, and Bradybaena similaris (Fe'russac)from May to September. The other pests such as Spodoptera litura (Fab.) and Trichoplusia ni Hubner are negligible due to their population density are so low. Applications of insecticides from April to June during the emergence period of 1st generation adults and from August to October during the emergence period of 2nd generation adults, resulted in the most effective control of Zeuzera coffeae and have the highest economic profit. The control method of Bradybaena similaris was to utilize the pet bottle instead of conventional chemical method. Improvement of culturing technique may decrease the occurrence of insect pests which may have favorable effect on their control. Discarded plant parts and abandoned field which may become the sources of infestation must be carefully taken care of. Strengthening of cooperative pest control program and searching for new control measures will eventually ensure overcoming of the difficulties encounted in the field.