The pediatric enterovirus is one of the common epidemic disease in the pediatric clinic, which is prevalent in hot and humid season from April to September each year. During the prevailing period, children who suffer from this disease should be quarantined at home accompanied with their parents. This phenomenon can be depicted as "One suffered and all tortured." so it pays a huge cost both in the society and family. In addition, more than 90% severe cases are concentrated in the children under 5, and the mortality rate is higher than 3.8%. Therefore, the enterovirus can be taken as a big threat to children's health. Western medicine is used to taking strategies of symptom treatment or maintenance treatment, and the benefit is limited to patients. In this article, it shows the core value of traditional Chinese medicine in developing individual treatments to different stages of pediatric enterovirus by distinct pathogeny and pathology analysis combined with syndrome differentiation and treatment of traditional Chinese medicine. We hope that we can take the advantages of traditional Chinese medicine to make the biggest benefit to the treatments of severe pediatric diseases.