『乳香』的檢驗與活性分析－兼談『金創膏』在傷口照護的進展

Identification and Biological Activity of Frankincense with Recent Progress in the Treatment of Non-healing Wound using Jinchuang Ointment

陸乃甄(Nai-Chen Lu) ； 賴尚志(Shang-Chih Lai) ； 何宗融(Tsung-Jung Ho) ； 陳灝平(Hao-Ping Chen)

《北台灣中醫醫學雜誌》 14卷2期 (2022/09) Pp. 17-32

摘要

『乳香』是橄欖科乳香屬卡氏乳香樹（Boswellia carterii Birdw.）或其同屬植物樹皮滲出的油膠樹脂，為中醫傷科常用藥。在臨床上，乳香最常配伍沒藥合併使用，也包括以治療糖尿病患慢性不癒合傷口著稱的『金創膏』。首先，我們以此中藥為例，說明其近期在照護傷口上的進展。近年來，由於過度採集與棲地遭受破壞，一些『乳香』原生樹種目前已經瀕危。市售的『乳香』商品，因而普遍存在有摻假的問題。本文首先簡述各種『乳香』的鑑定方法，比較他們之間的利弊，並且介紹最近新開發的技術，以基質輔助雷射脫附遊離飛行式質譜來鑑定『乳香』。文末也討論了『乳香』的各式生物活性，及可能的作用機轉。

關鍵字

11-羰基-β-乙醯乳香酸 ； 乳香酸 ； 乳香 ； 液相層析 ； 金創膏 ； 基質輔助雷射脫附遊離飛行式質譜 ； 沒藥 ； 薄層色層分析

並列摘要

Frankincense is a gum resin exuded by the bark of Boswellia carterii Birdw or the trees belonging to the genus Boswellia (family Burseraceae). It is widely used in traditional Chinese medicine. Frankincense and myrrh are frequently used together in the clinic, including the well-known herbal medicine, Jinchuang ointment. At first, we introduced the recent progress in treating non-healing wound using Jinchuang ointment. Because Boswellia trees face the problems of habitat loss and human overuse, adulterated frankincense products, therefore, appear on the market. Various methods for the identification of frankincense samples were compared here. Meanwhile, we also introduced the newly developed matrix-assisted laser desorption ionization-time of flight (MALDI TOF) mass spectrometry-based method to identify frankincense samples. Finally, frankincense's biological activities and possible working mechanisms were discussed.

並列關鍵字

acetyl-11-keto-β-boswellic acid ； boswellic acid ； frankincense ； high performance liquid chromatography ； jinchuang ointment ； matrix-assisted laser desorption ionization-time of flight mass spectrometry ； myrrh ； thin layer chromatography

參考文獻

張永勳，乳香，明通醫藥，486: 1，2017。

Ho TJ, Chen JK, Li TS, Lin JH, Hsu YH, Wu JR, Tsai WT, Chen HP. The curative effects of the traditional Chinese herbal medicine “Jinchuang ointment＂ on excisional wounds. Chinese Medicine. 15:41, 2020.

Hsu WH, Tsai WT, Hung SJ, Cheng HC, Hsu CH, Ho TJ, Chen HP. Treatment of Leprosy Wounds with “Jinchuang Ointment＂, a Traditional Chinese Herbal Medicine Complex. Leprosy Review. 90:460-468, 2019.

何宗融、陳灝平，談中藥『金創膏』於慢性不癒合傷口的治療及生物活性分析，北台灣中醫醫學雜誌，8: 13-20，2016。

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