This study discussed the influence of the capital expenditures, firm size, and R&D investment on enterprise performance. This paper used the database of Eurostat to analyze correlation among all variables. Moreover, this paper used the response surface model to find the interaction of each two independent variables which impact on enterprise performance. The results of this study displayed capital expenditures, firm size, and R&D investment significantly positive impacted on enterprise performance. Moreover, the interactions of independent variables significantly negative impacted on enterprise performance. The empirical results integrated the previous studies to suggest research topics for the future researchers. This study suggested that future research could focus on cross-cultural and cross-industrial differences. Therefore, this study expected to amend and construct the new structural model.