Squeeze film mechanisms play an important role in many areas of bio-lubrication and industrial applications such as synovial joints, clutch plates, matching gears, etc. In general, the effects of fluid inertia forces are neglected in the study of squeeze film performances. In engineering practices, squeeze films are often time-dependent oscillations. Therefore, the influences of fluid inertia forces show important. In the present paper, we are mainly concerned with the effects of fluid inertia forces in the squeeze film between a sphere and a plate. The results of the time-dependent film pressure are discussed through the variation of the Reynolds number and the amplitude of the oscillating film. In addition, the present results provide useful references for bio-lubrication and industrial engineering. Squeeze film mechanisms play an important role in many areas of bio-lubrication and industrial applications such as synovial joints, clutch plates, matching gears, etc. In general, the effects of fluid inertia forces are neglected in the study of squeeze film performances. In engineering practices, squeeze films are often time-dependent oscillations. Therefore, the influences of fluid inertia forces show important. In the present paper, we are mainly concerned with the effects of fluid inertia forces in the squeeze film between a sphere and a plate. The results of the time-dependent film pressure are discussed through the variation of the Reynolds number and the amplitude of the oscillating film. In addition, the present results provide useful references for bio-lubrication and industrial engineering.