Present research studies the performance of UAV propeller under different inclination angle and motor RPM using simulation method. The SolidWorks and ANSYS software are adopted to be the main software. The basic research object is US V-22 Osprey aircraft which can change the inclination angle of propeller to achieve the best flight performance according to task requirement. In the vertical mode, the plane can fly as a helicopter and fly as a fixed wing plane under horizontal mode. However, there is an obvious effect of power during different switching modes. The aerodynamic property of propeller during this variation process will be highlighted in this paper to obtain the best operation mode. The blade model is drawn via SolidWorks and simulated flow field under different boundary conditions using SolidWorks Flow Simulation and ANSYS Fluent. The setting of grid will be also analyzed to approach actual situation in the simulation process. The inclination angles are 0, 15, 30, 45, 60, 75 and 90 degree and the RPM of motor are 3000, 5000 and 10000. The side wind is fixed at 20 m/s. Results reveal the increasing of inclination angle, the wake flow will appear, and the induced drag will increase hugely. It makes the pressure difference decreases. In this study, the dynamic simulation technology of propeller will be developed to get power performance under different inclination angle and become a good reference which focus on the inclination angle-rotating speed interaction for UAV.