Chemoradiation for Olfactory Neuroblastoma

使用化學治療合併放射線治療於嗅神經母細胞瘤

楊舜如(Sheun-Ru Yang) ； 吳沅樺(Yuan-Hua Wu) ； 顏家瑞(Chia-Jui Yen)

《台灣癌症醫學雜誌》 2卷1期 (2015/03) Pp. 49-55

https://doi.org/10.6323/JCRP.2015.2.1.06

摘要

嗅神經母細胞瘤唯一罕見之鼻腔惡性腫瘤，目前尚未有嗅神經母細胞瘤的標準治療方法。目前最佳的方式為手術治療合併放射線治療，整體而言是為一預後良好之腫瘤，化學治療則使用於疾病復發或轉移。但若發生頸部淋巴結轉移則為不良預後因子。我們報告了一名36歲女性診斷為嗅神經母細胞瘤合併頸部淋巴結轉移，因考慮外觀而未接受手術治療。我們使用化學治療，合併放射線治療。腫瘤反應極好，並且未留下相關後遺症。我們同時回顧了嗅神經母細胞瘤的相關文獻，探討化學治療在嗅神經母細胞瘤之角色及治療反應，嗅神經母細胞瘤雖然對化療敏感，但仍需長期追蹤。

關鍵字

嗅神經母細胞瘤 ； 化學治療 ； 放射線治療

並列摘要

Olfactory neuroblastoma is a rare intranasal tumor, and the standard treatment for this disease remains controversial. Some clinicians contend that a combination of surgery and radiotherapy is the most efficacious approach, which frequently has a good prognosis. Chemotherapy is often reserved for those patients with tumor recurrence and distant metastasis. Regarding such metastasis, it is well-known that cervical metastasis indicates poor prognosis. We presented a 36-year-old woman who was diagnosed with a neuroblastoma with neck lymph node metastasis who did not undergo surgery. We treated her with chemotherapy followed by concurrent chemoradiation, and the result showed good response without sequela. We also reviewed the literature regarding the chemotherapy of olfactory neuroblastoma. In conclusion, olfactory neuroblastoma is highly sensitive to chemotherapy. However, long-term surveillanceof patients should be maintained in the event of local recurrence and distant metastasis.

並列關鍵字

olfactoryneuroblastoma ； chemotherapy ； radiotherapy