Bowen's Disease of the Nipple in a Woman with Tongue Cancer

舌癌病患與乳頭原位鱗狀細胞癌

黃振僑(Cheng-Chiao Huang) ； 張源清(Yuan-Ching Chang) ； 曾岐元(Chi-Yuan Tzen) ； 劉建良(Chien-Liang Liu) ； 劉滄柏(Tsang-Pai Liu)

《台灣癌症醫學雜誌》 2卷2期 (2015/06) Pp. 168-171

https://doi.org/10.6323/JCRP.2015.2.2.09

摘要

鮑恩氏病，或者稱作皮膚原位鱗狀細胞癌，是一種侷限於表皮的惡性腫瘤。通常好發暴露於陽光的皮膚部位，但其他位置也有可能產生。而乳頭原位鱗狀細胞癌是極為罕見的；在此，我們提出了一位有舌癌病史的中年女性，於乳頭發現皮膚原位鱗狀細胞癌。該患者接受了乳房切除術和前哨淋巴結切片檢查，迄今並無復發。據我們所知，這是舌癌病患出現乳頭原位鱗狀細胞癌在全世界首次的文獻報告。乳頭原位鱗狀細胞癌臨床上與Paget's disease極為類似。即使影像學檢查不能排除乳腺癌，如發現乳頭有鱗屑狀病灶，仍應考慮鱗狀細胞癌之可能性。

關鍵字

鮑恩氏病 ； 乳頭 ； 舌癌

並列摘要

Bowen's disease, or squamous cell carcinoma in situ (SCCIS) of the skin, is a malignant neoplasm restricted to the epidermis, without evidence of dermal invasion. It usually develops in sun-exposed areas of skin, but other sites can also be affected. However, Bowen's disease of the nipple is extremely rare. We present a case of Bowen's disease of the nipple in a middle-aged woman who presented with a scaly lesion on the nipple for several months. She also had tongue cancer and received surgical excision following concurrent chemoradiotherapy 10 years earlier. The patient was treated with a simple mastectomy and sentinel lymph node biopsy. To the best of our knowledge, this is the first reported case in the literature of Bowen's disease of the nipple in a woman with tongue cancer. Bowen's disease of the nipple clinically resembles Paget's disease. Therefore, even when diagnostic imaging cannot rule out breast cancer, squamous cell carcinoma should be included in differential diagnosis of scaly lesion of the nipple.

並列關鍵字

Bowen's disease ； nipple ； tongue cancer ； Paget's disease