A 69-year-old male patient, who had hypertension, dyslipidemia, and smoking, was referred to perform a treadmill myocardial perfusion imaging (MPI) after an episode of chest tightness. The stress and rest images revealed fixed perfusion defects in the inferoseptal, inferior, and basal anterior walls. However, respiratory motion was considered due to blurred mid to basal anterior and inferior walls, and distorted left ventricular chamber shapes. Motion correction by motion compensation technique was performed. The corrected images showed only mildly reversible perfusion defect in the inferior wall and apex. Respiratory motion is not uncommon for MPI using cadmium-zinc-telluride camera. Careful identification and correction help avoid misinterpretation of the images.