使用飛行時間與點擴散函數技術之F-18 FDG生理分布

Physiological Distribution of F-18 FDG Using Time-of-Flight and Point Spread Function Technology

李佩璇(Pei-Hsuan Li) ； 楊朝瑋(Chao-Wei Yang) ； 楊士頤(Shih-Yi Yang) ； 曾旭吟(Hsu-Yin Tseng) ； 邱南津(Nan-Tsing Chiu)

《核子醫學暨分子影像雜誌》 35卷3期 (2022/09) Pp. 83-90

https://doi.org/10.6332/ANMMI.202209_35(3).0001

摘要

背景：本研究的目的是建立使用飛行時間（time-of-flight, TOF）與點擴散函數技術（point-spread-function, PSF）影像重建技術後，在沒有罹癌且已知異常的受檢者器官組織中之2-deoxy-2-[^(18)F]fluoro-D-glucose（F-18 FDG）的生理攝取分布。方法：本回溯性研究收集從104年1月至104年6月間為了健康檢查而進行全身FDG- positron emission tomography/computed tomography（PET/CT）掃描，經篩選後總共有107位受檢者（男性50位，女性57位）符合條件。FDG-PET/CT影像使用ordered subset expectation maximization（OSEM）+TOF + PSF，再利用影像後處理軟體圈選不同器官和組織感興趣區域（region of interest, ROI），獲得FDG PET/CT的最大和平均標準攝取值。結果：顯著攝取FDG的器官組織（平均SUVmax ＞ 2.5）包括小腦（6.57 ±1.32）、軟顎（2.84 ± 0.66）、腭扁桃體（4.57 ± 1.48）、舌扁桃體（3.78 ± 1.20）、舌下腺（3.48 ± 1.05）、心肌（4.63 ± 3.55）、肝臟（3.34 ± 0.43）、直腸括約肌（2.97 ± 0.67）和睪丸（2.88 ± 0.50）。結論：了解整個身體的FDG生理攝取對於提高影像判讀的精確度是有價值的。

關鍵字

標準攝取值 ； 點擴散函數 ； 生理分布 ； 飛行時間

並列摘要

Background: The purpose of this study was to establish the physiologic distribution of 2-deoxy-2-[^(18)F] fluoro-D-glucose (FDG) (F-18 FDG) on positron emission tomography (PET)/computed tomography (CT) images reconstructed by time-of-flight (TOF) and point-spread-function (PSF) image reconstruction techniques in patients without cancer history and known abnormalities in organ and tissue. Methods: We retrospectively included a total of 107 patients (50 males and 57 females) who underwent whole body FDG PET/ CT between January 2015 and June 2015. By drawing regions of interest in different organs and tissue on FDG PET images reconstructed with ordered subset expectation maximization (OSEM) + TOF + PSF, we explored the effects of TOF and PSF on maximum and average standardized uptake values (SUVs). Results: Organs or tissue with significant FDG uptake (i.e. mean SUVmax ＞ 2.5) included the cerebellum (6.57 ± 1.32), soft palate (2.84 ± 0.66), palatine tonsils (4.57 ± 1.48), lingual tonsils (3.78 ± 1.20), sublingual glands (3.48 ± 1.05), myocardium (4.63 ± 3.55), liver (3.34 ± 0.43), rectum sphincter (2.97 ± 0.67) and testis (2.88 ± 0.50). Conclusions: For improving the accuracy of interpretation, it is valuable to know the physiological uptake of FDG over the whole body.

並列關鍵字

physiologic distribution ； Point-Spread-Function ； standardized uptake values ； Time-Of-Flight