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Impact of sex on the early and long-term outlook of patients undergoing carotid artery stenting with a single embolic protection device-stent combo

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Aims: Whether men and women benefit similarly from carotid artery stenting (CAS) remains uncertain. We hypothesized that CAS, especially when performed with the same combination of embolic protection device (EPD) and stent, may have a different risk-benefit profile in men and women. Methods: We retrospectively collected data on all patients undergoing CAS with the Angioguard EPD and Precise RX stent. A total of 447 patients were included, 285 (64%) men and 162 (36%) women. Results: Despite several baseline, lesion and procedural differences, procedural success and clinical outcomes were similar (all p > 0.05), at both discharge and longterm follow-up (19±21 months). Specifically, the composite of death, myocardial infarction, stroke or transient ischemic attack occurred in 5 (2%) men and 2 (1%) women at discharge, and 32 (11%) men and 12 (7%) women at follow-up (both p > 0.05). Even after propensity score matching, no significant differences were found (all p > 0.05). Conclusion: In conclusion, despite several baseline disparities, there are no differences in the early and long-term incidence of adverse events in men versus women undergoing CAS.

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