The Genes Associated with RNA Editing and Glioma on the Chromosome 22q

G. Wang ； Y. Tian

《International Journal of Advance in Medical Science》 2卷 (2014/12) Pp. 8-12

並列摘要

It is well known that RNA editing plays a critical role in glioma progress. The most frequent RNA editing mechanism is controlled by the ADAR (adenosine deaminase acting on dsRNA) family of enzymes. The recent researches proved that there is a great quantity of new ADAR editing sites in 1637 kinds of genes. Whether these genes connect with RNA editing or ADAR on glioma is still unknown. To clarify the possibility of those genes connect with RNA editing on glioma, we arrange those genes according to the most frequent chromosome imbalances in primary glioma, which suggests that most of those genes are concentrated on chromosome 22q. Furthermore, there are 8 genes (TXNRD2, ADRBK2, THOC5, APOL1, APOL6, PISD, ARSA and GGA1) associated with glioma, meanwhile, 3 genes (ADRBK2, THOC5 and APOL1) associated with gene transcription, and the TXNRD2 associated with post-transcription regulation in human medulloblastoma cells. On the other hand, 8 genes (APOBEC3D, POLDIP3, SAPS2, GNB1L, FLJ23588, DMC1, NUP50 and POLR2F ) are associated with RNA composition, although without connection with glioma. At present, none of them is reported to be associated with RNA editing or ADAR on glioma. Overall, those 16 genes which may have connection with glioma or RNA composition, suggest the existence of new ADAR editing sites which are potential candidates in charge of RNA editing on glioma.

並列關鍵字

RNA Editing ； Glioma ； Chromosome 22q