- 期刊
- OpenAccess
Radiosynthesis and Biological Evaluation of [^(111)In]-5, 10, 15, 20-Tetrakis (Pentafluorophenyl) Porphyrin Complex as a Possible Imaging Agent
並列摘要
Porphyrins are interesting derivatives with low toxicity, tumor avidity, and rapid wash-out suggested as potential radiopharmaceuticals in radiolabeled form. In this work, [^(111)In] labeled 5, 10, 15, 20-tetrakis (pentafluorophenyl) porphyrin ([^(111)In]-TFPP) was prepared using freshly prepared [^(111)In]InCl3 and 5,10,15,20-tetrakis (pentafluorophenyl) porphyrin (H_2TFPP) for 60 min at 100C (radiochemical purity: ＞99% ITLC, ＞99% HPLC, specific activity: 13-14 GBq/mmol). Stability of the complex was checked in final formulation and human serum for 48 h. The partition coefficient was calculated for the compound (log P=0.69). The biodistribution of the labeled compound in vital organs of wild-type rats and fibrosarcoma-bearing mice was studied using scarification studies and SPECT up to 24 h. A detailed comparative pharmacokinetic study performed for 111In cation and [^(111)In]-TFPP performed up to 24h. The complex is mostly washed out from the circulation through kidneys and liver. The tumor:blood and tumor: muscle ratios 24 h post injection were 1.44 and 66 respectively.
延伸閱讀
- Tu, C. C. (2007). Kinetic Investigation of Ethylene/Norbornene Polymerization and Copolymerization Using Methylpalladium(II) Catalysts with α-Amino-Pyridine Ligands [master's thesis, National Taiwan University]. Airiti Library. https://doi.org/10.6342/NTU.2007.02815
- Lin, Y. C. (2006). Investigation of Ethylene/Norbornene Copolymerization Using Cationic Methylpalladium(Ⅱ) Catalysts with Amino-Pyridine Ligands [doctoral dissertation, National Taiwan University]. Airiti Library. https://doi.org/10.6342/NTU.2006.00282
- Bala, M., & Mishra, L. K. (2014). Complexing Behaviour and Antifungal Activity of N-[(1E)-1-(1H-Benzimidazol-2-yl)ethylidene]morpholine-4-carbothiohydrazide and Related Ligand with Metal Ions. International Journal of Inorganic Chemistry, 2014(), 98-107. https://doi.org/10.1155/2014/902575
- 施凱庭（2016）。Synthesis of Stereoisomers of 4-(3-Fluoropropyl)-L-glutamic acid and 3-[4-nitro-fluorophenyl]propyl Synthon for the Development of Novel PET Imaging Agents〔碩士論文，國立臺灣大學〕。華藝線上圖書館。https://doi.org/10.6342/NTU201603222
- Su, Y. Y. (2007). SYNTHESIS AND CHARACTERIZATION OF COLORLESS FLUORINATED POLYIMIDES, ORGANOSOLUBLE POLYNAPHTHALIMIDES AND POLYIMIDE/SILICA HYBRIDS DERIVED FROM AROMATIC BIS(ETHER AMINE)S BEARING TRIFLUOROMETHYL GROUPS [doctoral dissertation, Tatung University]. Airiti Library. https://www.airitilibrary.com/Article/Detail?DocID=U0081-0607200917240807