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Spectrophotometric Determination of Hydroxyurea and Stability in Nitric Acid Medium
並列摘要
A spectrophotometric method has been developed for the determination of hydroxyurea. The methodology involves the reduction of standard potassium permanganate (KMnO_4) prepared in 1N sulfuric acid medium by hydroxyurea (HU). KMnO_4 is having λmax at 525 and 545 nm. The decrease in absorbance for a given KMnO_4 solution by the addition of HU is compared to the solution without HU having the same concentration of KMnO_4. Molar absorption coefficient (ε) value is found to be 957 mol^(-1) L cm^(-1) with a precision of 3.8%. The correlation coefficient was 0.9975. The linear dynamic range of this method was found to be 10 to 80 ppm of HU. Effect of acidity and temperature on the stability of HU in nitric acid medium was also studied. Acid dependence on radiation effect of HU solution and dose dependence of stability of HU solution were also studied.
延伸閱讀
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