高糖化血色素HbA1c引發心血管疾病的風險

High HbA1c Lead to Cardiovascular Disease Risk

邱淑玲(Shu-Ling Chiou) ； 陳家綺(Chia-Chi Chen) ； 傅文玫(Wen-Mei Fu) ； 李慶孝(Ching-Hsiao Lee) ； 林祐君(You-Jung Lin) ； 陳尚延(Shang-Yan Chen) ； 鄭惠文(Cheng Hui Wen) ； 曾瑞壯(Jui-Chuang Tseng) ； 吳宇暉(Yu-Hui Wu)

《檢驗及品保雜誌》 3卷4期 (2014/11) Pp. 185-189

https://doi.org/10.6573/JTQA.201411_3(4).06

摘要

糖尿病是台灣常見的慢性疾病之一，心血管疾病是糖尿病人醫療支出中最大的病因，且病患常常因併發心血管疾病而死亡。因此，本研究係以糖化血色素（HbA1c）為標準，檢測血中cholesterol、triglyceride、Low-density lipoprotein（LDL-C）、C-reactive protein（CRP）等心血管指標，來評估糖尿病患心血管疾病的風險。結果顯示，triglyceride與CRP，無論糖尿病控制良好與否，其平均值皆大於正常值。而cholesterol、triglyceride、LDL-C與CRP隨著HbA1c的值越高，其濃度也相對越高。總之，糖尿病患不但具有較高的心血管疾病風險，並且如果控制不良，其心血管疾病的風險也越高。

關鍵字

糖化血色素（HbA1c） ； 心血管疾病

並列摘要

Diabetic mellitus is one of the common chronic diseases in Taiwan. Cardiovascular disease is the etiology of the biggest medical expenses in patients with diabetes, and patients with diabetes often die due to concurrent cardiovascular diseases. Therefore, this study used HbA1c as a standard and evaluated the risks of cardiovascular diseases for patients with diabetes by investigating their cardiovascular indices such as cholesterol, triglyceride, low-density lipoprotein- cholesterol (LDL-C) and C-reactive protein (CRP). The results showed that no matter whether the diabetes is under well control or not, the average values of triglyceride and CRP are both higher than the normal values. In addition, the concentrations of cholesterol, triglyceride, LDL-C and CRP are higher in accordance with the concentration of HbA1c. We conclude that patients with diabetes not only have higher cardiovascular risks, but also have even higher cardiovascular risks if the diabetes control is poor.

並列關鍵字

Glycosylated hemoglobin ； HbA1c ； Cardiovascular disease