Antioxidant Effects of Vitamin E in Diabetes Mellitus Type 1

Alarcón-Martínez Y ； Alonso-Rodríguez D ； Moreno-Téllez E ； Dra. Idalia Morell Amarales

《International Journal of Clinical Pharmacology & Toxicology (IJCPT)》 2卷3期 (2013/03) Pp. 63-65

並列摘要

In diabetes mellitus atherosclerosis is precocious, accelerated, and extensive, having influence to a large extent the secondary dislipoproteinemia to the hyper-glucemia, the lipoprotein's glucosilation produce changes in them same, that more aterogenics make them and generate free radicals that provoke oxidation of the apoprotein of the lipids and close macromoleculs, decided to evaluate the presence of oxidative stress in children with diabetes mellitus type1 and demonstrating the need of antirust as part of the pharmacologic therapy of this disease, selected 30 patients with Diabetes mellitus type 1, of the consultation of endocrinology of the Pediatric Provincial Teaching Hospital. Dr. Eduardo Agramonte Piña of Camaguey they took in the period of august to november of 2012. with ages between 5 and 16 years, under informed consent you show of blood for the determination of total cholesterol, Triglicerides, LDL Colesterol, HDL Cholesterol, uric acid, vitamin C, bilirrubin, glucemia, ceruloplasmin, albumin and LDL oxidized, they administrated Vitamin E (400mg daily), during three months, coming true the determinations in each month and comparing the results obtained before and after therapy. Before the treatment 93% of patients LDLox enlarged with at least one of the seric antioxidant lessened, when the levels concluded the study presented levels lifted of glucemia and the 100% of antirust they increased and the LDLox decrease was significant in 100% of the patients, keeping invariable the levels of lipids. Data were processed by means of descriptive statistics, with absolute and relative frequency distribution, coming true a hypothesis testing for matching observations in each complementary.