- 期刊
The inhibitory effect of clindamycin on Lactobacillus in vitro
摘要
Objective: To evaluate the in vitro effect of varying concentrations of clindamycin on Lactobacillus spp. Methods: Concentrations of clindamycin ranging from 1.95-20 000 mg/ml were studied for their effect on the growth of six strains of Lactobacillus. Results: Clindamycin concentrations between 1.95-31.25 mg/ml had no statistically significant effect on growth of lactobacilli (p ＞ 0.05). Concentrations 125 and 250 mg/ml had a bacteriostatic effect. The mean minimum inhibitory concentration (MIC) for studied Lactobacillus strains was determined as 1000 mg/ml. Conclusion: High concentrations of clindamycin achieved in the vagina by intravaginal application might be inhibitory for Lactobacillus.
延伸閱讀
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