- 期刊
PERIOPERATIVE PROPHYLACTIC CHEMOTHERAPY OF ECHINOCOCCUS GRANULOSUS: DETERMINATION OF MINIMUM EFFECTIVE LENGTH OF ALBENDAZOLE THERAPY IN IN VITRO PROTOSCOLEX CULTURE
摘要
Protoscoleces of Echinococcus granulosus were cultured in vitro in 500, 250 or 100 mg/l albendazole sulphoxide for 1, 3, 7, 10, 14d and then 'rescued' (R) into drug-free medium for the remainder of the culture period. Successful minimum lengths of therapy were much longer than for praziquantel, and only at 500 mg/l was the 10dR treatment as effective as continuous therapy for 28d. Treatment with 100 mg/l both in continuous culture and in the 'R' experiments was ineffective over a 35d period. The results are compared with those from similar experiments using praziquantel.
延伸閱讀
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