Radiation-induced leiomyosarcoma: does antimetabolite chemotherapy contribute? A report of three cases

BRUCE BROCKSTEIN ； ARNO MUNDT ； DANIEL J. HARAF ； MARK FERGUSON ； ANTHONY MONTAG

《Sarcoma》 2003卷 (2003/12) Pp. 167-172

https://doi.org/10.1080/13577140310001650330

摘要

Purpose: Radiation therapy in low and high doses is known to be associated with the occurrence of late secondary sarcomas. The addition of chemotherapy has not been clearly demonstrated as a contributing factor. We describe three patients with radiation-associated leiomyosarcoma who had also received antimetabolite chemotherapy. Methods: Three cases of leiomyosarcoma occurring 9–27 years after radiation and antimetabolite chemotherapy are presented, along with histopathological details. A Medline search was used to assess prior reports of leiomyosarcoma after radiation. Results: These three cases appear to be the first reported in which leiomyosarcoma followed therapy with radiation and antimetabolites. Discussion: With the increasing use of antimetabolite therapy combined with radiation, there is the potential for more occurrences of leiomyosarcoma or other post-treatment sarcomas.

關鍵字

leiomyosarcoma ； radiation ； chemotherapy ； antimetabolite ； secondary malignancy