磁振造影及活體質子磁振光譜在神經退化性疾病之腦部能量代謝的研究

The Effect of Brain Energy Metabolism on Neurodegenerative Diseases Using MRI and MRS

李長欣(Chang-Shin Lee) ； 張程(Chen Chang) ； 李旺祚(Wang-Tse Lee) ； 祁業榮(Theresa Chyi)

《化學》 57卷3期 (1999/09) Pp. 253-258

https://doi.org/10.6623/chem.1999033

摘要

磁共振技術已被成功地應用在醫學及生理方面，磁振造影及磁振光譜的結合運用可以讓我們非侵入性地得到結構及生理，生化功能的資訊。我們利用粒線體毒物3- nitropropionic acid的動物模式，介紹磁共振技術應用在神經退化性疾病之研究。這些磁共接技術，亦可應用在臨床的話斷及其它腦部疾病的研究上，提供未來可能的治療策略。

關鍵字

磁振造影 ； 活體質子磁振光譜 ； 神經退化性疾病 ； 粒線體毒物

並列摘要

Magnetic resonance (MR) methods are widely available on medicine and physiology. The combination of magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) allow the noninvasive investigation of anatomy, physiology and biochemical processes in living animals and humans. Examples of the 3-nitropropionic acid-intoxicated animal model are given to demonstrate the application of MR methods for the investigation of neurodegenerative disease. The MR methods demonstrated here can also be applied for the diagnosis of many neurological diseases, and provide possible therapeutic strategies in the future.

並列關鍵字

magnetic resonance imaging (MRI) ； in vivio ^1H magnetic resonance spectroscopy (MRS) ； neurodegenerative disease ； mitocbondrial toxin