摘要
核酸分子可以和去氧核醣核酸、核醣核酸、蛋白質、或是其他一些生物分子相互作用，進而抑制這些分子的功能。在這篇文章中，我們討論了六種具有序列特異性及兩種非序列特異性的核酸分子的反應。基本上，反意、反基因及誘餌寡核酸、核酶、矯正基因點變具的寡核酸和適合體均具有序列特異性的功能，另一方面來說，會CG雙核苷的核酸和硫代磷酸修飾的寡核酸則具有非序列特異性的生物功能。核酸藥物與傳統化學治療藥物有別的是，一般化療藥物對於細胞是具有毒性的，但是核酸藥物能針對瘤細胞中基因的過度表現或作用加以改正，不影響到正常細胞的特性是可以預期的。這些理論將在文章中討論。
並列摘要
Nucleic acids are able to interact with DNA, RNA, protein or other biomolecules thereby inhibit their function. Six types of sequence-specific and two types of non-sequence-specific interaction were discussed in this article . Basically, antisense, antigene, decoy, ribozyme, mutation corrector and aptamer oligonucleotides possess sequence-specific function. On the other hand, CG-containing nucleic acid and phosphorothioate oligonucleotide possess some non-sequence-specific biochemical functions. Different from traditional chemotherapeutic drugs, which usually poison the cells, nucleic acid drugs suppress abnormal cellular function in cancer cells thus differential influence on normal cells from cancer cells could be expected. The rationales are discussed.