發現的藝術─生物物理有機化學的故事

The Art of Discovery in Biophysical Organic Chemistry

柯壽偉(Edward M. Kosower) ； 洪浩鈞(Haw-Chiung Horng) ； 周大新(Tashin J. Chow)

《化學》 63卷2期 (2005/06) Pp. 281-287

https://doi.org/10.6623/chem.2005023

摘要

細心的觀察吡啶鹽添加物的實驗，引導出物理有機化學上一系列重要的發現。如何掌握新發現的契機是種藝術；不是目標導向的死板邏輯可以達到的。掌握發現的藝術需要具備豐富的經驗和敏銳的直覺，才能夠即時辨識出異常的現象，再經由努力提供出合理的解釋。本文舉出幾個例子，描述如何經由意外發現的光譜吸收，逐步建立出一整套的新型溶劑效應理論，以及又如何進一步發現一系列漂亮而穩定的有機自由基分子。

關鍵字

溶劑效應 ； Z值 ； 吡啶碘鹽 ； 電荷轉移 ； 創造性

並列摘要

Observations made in the course of experiments on pyridinium salts led to important discoveries in physical organic chemistry. The way in which the discoveries were made is likened to art rather than goal-directed ＂cold logic＂. We can describe the art of discovery as an effort enhanced by practice and intuition to recognize novelty in a finding and provide productive insight into its nature. We shall present some examples, and describe what happened after finding an unexpected light absorption band, a surprising solvent effect on spectra, and an unexpectedly stable and beautiful small organic radical.

並列關鍵字

Solvent polarity ； Z values ； charge-transfer complex ； pyridinyl radical