蛋白體學的應用－生物標記的發現

The Application of Proteomics: Biomarker Discoveries

楊雪慧(Hsueh-Hui Yang)

《化學》 65卷3期 (2007/09) Pp. 281-285

https://doi.org/10.6623/chem.2007028

摘要

臨床生物標記的應用包括了解致病原因、早期發現疾病、追蹤治療的效果及發展新藥。雖然臨床生物標記的應用性很多，但目前只有少數的臨床生物標記被發現，且大多數臨床上應用的生物標記 (例如診斷前列腺癌的前列腺抗原 (PSA) 及診斷卵巢癌的CA-125) 對疾病都缺乏專一性及靈敏性。因此，發現新的臨床生物標記是一個十分重要的主題。蛋白體學的研究有助於發現新的臨床生物標記而成為臨床研究的焦點。本篇文章整理最近蛋白體學於臨床上疾病的生物標記之發現的進展。

關鍵字

蛋白體學 ； 生物標記

並列摘要

Biomarkers may be applied to the understanding of the mechanism of disease, early diagnosis, prediction of the effect of the therapy and finding new drugs. Although the applications of biomarkers are useful, only few biomarkers are found and used in the clinical area. Besides, most clinically established markers (e.g. prostate specific antigen (PSA) for prostate cancer, cancer antigen CA125 for ovarian cancer) are lack of sensitivity and specificity. Therefore, the discovery of new biomarkers is a hot area. Due to the proteomics research has the potential of identification of biomarkers, it becomes a focus of the clinical research. This paper reviews the progress of biomarker discovery in the clinical research through proteomics.

並列關鍵字

Proteomics ； Biomarker