細胞週期的新標靶在抗癌藥物的發展

New Targets in Cell Cycle for New Antitumor Agents Development

羅宇翔(Yu-Hsiang Lo) ； 林志峰(Chi-Fong Lin) ； 楊世群(Shyh-Chyun Yang) ； 吳明忠(Ming-Jung Wu)

《化學》 66卷4期 (2008/12) Pp. 293-308

https://doi.org/10.6623/chem.2008029

摘要

在這篇回顧文裡介紹細胞週期間新標靶，包括週期素和週期素依賴性激酶結合形成複合物(Cyclin/CDK complex)、polo-like kinases (PLKs)、Aurora kinases和驅動蛋白(KSP)。許多的研究指出這些作用在新的標靶的化合物可以避免傳統抗癌藥物在化學治療時所會出現的副作用。我們相信在這篇論文所介紹的將會成為抗癌藥物發展的新潮流。

關鍵字

細胞週期 ； 抗有絲分裂試劑 ； 抗癌藥物

並列摘要

This review article displays some new proteins in cell cycle, such as Cyclin /CDK complex, polo-like kinases (PLKs), Aurora kinases and Kinesins spindle protein (KSP). These new proteins are the new targets for new antitumor agent development. Many researches found that compounds could inhibit these new targets would show good growth inhibition activity against human tumor cell lines and avoid the side effect of chemotherapy by the traditional antitumor drugs. We believe that the information disclosed in this article will be a new current for the development of new anticancer drugs.

並列關鍵字

Cell cycle ； Antimitotic agent ； Anticancer agent