樹狀型聚合物作為藥物或基因載體之應用

相較於傳統之聚合物，具有近球型之分支構造的樹狀型聚合物，有可定義之構型、較均一之分子量分佈；且透過逐步合成步驟，可得到易準確控制的分枝數和分子大小，以及便於在外圍進行衍生之分子。此類分子在各領域之應用甚多且廣，本論文主歸納近期樹狀型聚分子做為傳輸系統之應用，並學習其結構特色。因其特殊之分子結構，樹狀型分子可形成較親脂性的內部空間和多重官能基外圍，尤其在第三代以上之分子，可以利用物理吸附或化學鍵結等方式與包覆之客分子如藥物或基因等作用。樹狀型聚合物與藥物間常見之鍵結架橋、藥物由載體釋出之機制、和降低載體毒性之修飾等研究，亦為本文討論之範疇。文獻記載清楚指出透過樹狀型聚合物為載體與客分子所形成之複合物，能有效地改善客分子的水溶性、安定性；增進複合物在細胞穿透或組織之分佈；且具有控制釋放，甚至標靶傳輸等目的，使許多藥物或基因治療之成效大幅提高。

關鍵字

樹狀型聚合物；藥物攜帶；基因轉染；水溶性

並列摘要

In contrast to the traditional polymers, dendrimers with globular branched structure can be considered to possess defined and monodisperse conformation. By iterative synthetic approaches, the number of branches on dendrimer and its size can be precisely controlled and the exterior functionality can be regulated conveniently, though. In fact, dendrimer demonstrates hundreds of applications, we will focus on current researches related to delivery systems and learn the structure features. According to its unique structure, dendrimer will form a hydrophobic interior space and multiple functionalities on the periphery, especially the generation greater than 3. Dendrimer will offer either physical entrapment or chemical attachment to host the guest molecules such as drug or gene. Herein, the discussions include the common linkage used between dendrimer and drug, the mechanism that drugs released, and the modification for diminishing the toxicity of dendrimer. These studies clearly indicate that incorporation with dendrimer can significantly improve solubility and stability of the guest molecules, and the complex enhances the penetration ratio into cell and distribution in tissue. Moreover, dendrimer may offer more benefits to improve the efficiency of drug or gene therapy including controllable drug release and targeting delivery.

並列關鍵字

Dendrimer ； Drug carrier ； Gene transfection ； Water solubility

國際替代計量

樹狀型聚合物作為藥物或基因載體之應用

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