Biomaterials used in the field of pharmaceutics and medicine in vivo or in vitro must be the prosperities of biocompatibility and bio-functional. It can be replaced the function from the original tissue or organ by temporary or long-term. Biomaterials can be divided into metals, ceramics, polymers and biological composite materials, in which the multi-functional polymer with biodegradable materials, such as those common polysaccharides and protein and other natural polymer with ester, amide, etc. The polymer-based artificial groups, can be widely used in applications in drug delivery, tissue engineering and regenerative medicine.