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明膠奈米粒子於藥物傳輸之發展與應用

Gelatin Nanoparticles for Drug Delivery Applications

摘要


明膠(gelatin)為膠原蛋白(collagen)經處理後萃取所得的產物。明膠於生物醫學上的應用,因其具有生物降解性、生物相容性、無毒性等優點,而使其應用範圍廣泛。關於以明膠奈米顆粒作為藥物釋放及基因遞送載體之研究相當熱絡。而在本篇文章中,我們主要介紹其作為抗癌藥物載體之研究及應用。

並列摘要


Gelatin, which is derived from collagen, is a commonly used natural polymer for biomedical application. The isoelectric point of gelatin can be modified during the fabrication process to make either a negatively or positively charged gelatin nanocarrier. Various forms of gelatin nanocarrier can be fabricated by desolvation method for controlled release studies. Studies have been performed that gelatin nanocarriers are able to encapsulate drug/DNA or chemical reaction with ligand for specific targeting delivery. This review will emphasize how gelatin nanoparticle were fabricated and the application of EGFR targeted gelatin nanoparticles for chemodrug delivery.

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