動物體內奈米粒子檢測分析技術

In-vivo Monitoring of Nanoparticles in Anesthetized Rats

蘇正寬(Cheng-Kuan Su) ； 黃靖雯(Chin-Wen Huang) ； 孫毓璋(Yuh-Chang Sun)

《化學》 69卷1期 (2011/03) Pp. 57-67

https://doi.org/10.6623/chem.2011007

摘要

當全世界科學家都在積極利用各式奈米材料特殊的物理化學特性，希望創造各種新的技術，以增進人類的生活品質的同時，也有許多科學家正深入調查評估這些新的奈米材料可能導致人體健康或是生態環境的負面影響；另外，近年來，隨著奈米毒理學與生物相容性的研究發展，奈米材料的臨床效果與風險分析引發更多的疑問。在了解各式奈米材料藥理及毒理特性的過程中，一般均須藉由完整的藥物動力學或毒理動力學的收集，才能確實掌握這些外源性物質在活體動物體內的作用機轉。為滿足生物醫學領域亟欲窺探奈米毒理學及藥理學的需求，本文將針對現今文獻中生物體內奈米粒子檢測分析技術的發展現況提出討論。

關鍵字

生物體 ； 奈米粒子 ； 檢測分析技術

並列摘要

Compared to bulk materials, because of quantum size effects and large surface area to volume ratio, nanomaterials have been proven to be a versatile substrate for different applications. As the nano-related industry continues to grow, nanotoxicology has become an emerging branch of toxicology that concerns itself with characterising the adverse effects resulting from the interactions between nanomaterials and biological systems explored. From the pharmacological and toxicological standpoints, before nanomaterials gains approval and enters into their practical uses, we must have the thoroughgoing understanding about its pharmaco- or toxico-kinetics information and disposition [absorption, distribution, metabolism, elimination (ADME)]. In terms of pharmacokinetics and toxicokinetics, the development of a useful analytical method is of utmost importance, since the accurate determination of the concentration of the substance of interest is indispensable in understanding the pharmacodynamic and toxicodynamic actions of nanomaterials.

並列關鍵字

Biological samples ； Nanomaterials ； Analytical method