可對碳氫化合物C-H鍵進行氧化催化的含銅金屬離子錯化物之發展

Recent Developments of the Copper Complexes in Catalyzing the Oxidation of Aliphatic C-H Bond

陳炳宇(Peter Ping-Yu Chen)

《化學》 69卷2期 (2011/06) Pp. 149-158

https://doi.org/10.6623/chem.2011014

摘要

將甲烷轉化成甲醇是催化化學的一個重要挑戰。它目前也是能源上的一個重要議題。目前工業製程雖然可以進行但必須在高溫高壓的條件下，然而自然界中的甲烷單氧化酵素卻可以在室溫常壓下輕易進行。如何把如此完美的設計轉換成一具有高效率的催化劑，是生物無機化學一個相當熱門的話題，已知微粒體甲烷單氧化酵素pMMO中，其催化反應中心包含銅離子，然而針對pMMO酵素活性中心銅離子數目仍有很大的爭議，根據目前文獻記載，可催化脂肪族碳氫化合物C-H鍵的錯化物從一個銅離子至四個銅離子都有報導，本文將收集文獻中從pMMO的理論計算與目前具有C-H鍵催化活性的銅離子錯化物的發展做一簡要介紹。

關鍵字

微粒體甲烷單氧化酵素 ； C-H鍵催化 ； 銅離子錯化物

並列摘要

Direct converting methane into methanol is still an enormous challenge nowadays. It is also a very significant issue with regard to the alternate energy in lieu of fossil fuel. Although it is able to be manufactured by industrial mass production, it needs to be carried out under high temperature and pressure with catalyst. Nevertheless the particulate methane monooxygenase, pMMO, is able to facilely achieve this chemistry under merely ambient temperature and pressure with marvelous efficiency and conversion. It is known that the pMMO is a copper protein containing multi-copper ions, but there are still several debates in the location of active site and quantity of copper ions. According to many literatures presently, the copper catalysts which may accomplish the oxidation of aliphatic C-H bond include mono-, di-, tri-, and tetra-copper ions. In the text, we will briefly introduce this subject from the theoretical calculations of pMMO to the development of the copper catalyst.

並列關鍵字

pMMO ； Tricopper ； Dicopper ； Catalysis