無機配位化學在生物化學中之應用：雙亞硝基鐵錯合物

Application of Inorganic Coordination Chemistry in Biological Chemistry: Dinitrosyl Iron Complexes

魯才德(Tsai-Te Lu) ； 廖文峯(Wen-Feng Liaw)

《化學》 71卷4期 (2013/12) Pp. 319-327

https://doi.org/10.6623/chem.2013031

摘要

由於過渡金屬在生物體中所扮演重要的功能與角色，刺激了生物無機化學此領域的發展。生物無機化學乃利用無機配位化學的概念，將金屬離子視為活性中心，蛋白質或去氧核醣核酸 (DNA)作為配體，探討金屬離子在生物體中扮演的角色，將無機配位化學的概念運用於生物化學中。本文將利用一氧化氮為例，介紹在生物系統中發現具有生物活性及意義的無機配位錯合物後，如何利用無機合成的方法，配合上物理光譜的探討，了解一氧化氮自產生之後，如何與含鐵蛋白質作用產生雙亞硝基鐵錯合物，並以此形式穩定一氧化氮，在生物體中運送一氧化氮並釋放給一氧化氮的目標蛋白，達到訊息傳遞的功能。

關鍵字

生物無機化學 ； 一氧化氮 ； 雙亞硝基鐵錯合物

並列摘要

Bioinorganic chemistry has emerged as an important research area due to the importance of transition metals in the biological system. Bioinorganic chemistry explores how the interplay between transition metals and biomolecules, such as proteins and DNA, facilitates the processes supporting our daily life. In this report, nitric oxide will be used as an example to demonstrate how an inorganic chemist can (1) synthesize biomimetic complexes, (2) investigate the electronic structure of biomimetic complexes with various physical methods, (3) establish new probes to identify different inorganic complexes, and (4) utilize the biomimetic complexes as an exogenous reagent to achieve NO-related function, after they were inspired by the discovery of dinitrosyl iron complexes (DNICs) upon nitrosylation of Fe-containing proteins.

並列關鍵字

Bioinorganic chemistry ； Nitric oxide ； Dinitrosyl iron complexes