自組裝胜肽水凝膠之分子設計與應用

Molecular Design and Application of Self-assembled Peptide Hydrogels

林欣杰(Hsin-Chieh Lin)

《化學》 80卷4期 (2022/09) Pp. 353-367

https://doi.org/10.6623/chem.202209_80(4).010

摘要

由於在組織工程、再生醫學、蛋白質分離、細胞治療、藥物載體和感測器等方面的各種應用性，胜肽衍生物的分子自組裝之超分子水凝膠最近引起了廣泛關注。超分子水凝膠是由非共價鍵作用力所形成的三維網絡，因此更具生物相容性，常見的自組裝胜肽種類有小分子胜肽、胜肽兩親物、兩親胜肽和類表面活性劑胜肽，其中小分子胜肽由於結構簡單、組成可調和獨特的超分子結構而備受矚目。在這篇綜述中，我們針對小分子胜肽的分子設計及其在生物醫學上的應用進行討論，希望能為有興趣探索以超分子水凝膠作為生物材料的研究人員提供更多的介紹與參考。

關鍵字

水凝膠 ； 水凝膠因子 ； 自組裝 ； 胜肽 ； 生醫材料

並列摘要

Due to various applications in tissue engineering, regenerative medicine, protein separation, cell therapy, drug carriers, and sensors, supramolecular hydrogels based on molecular self-assembly of peptide derivatives have recently attracted widespread attention. Supramolecular hydrogel is a three-dimensional network formed by non-covalent bond forces that have highly biocompatible for many biological systems. Self-assembling peptides have four categories: small-molecule peptides, peptide amphiphiles, amphipathic peptides, and surfactant-like peptides. Recently, small molecule peptides have attracted much attention due to their simple structure, tunable composition, and unique supramolecular structure. This review provides a general introduction for researchers interested in exploring supramolecular hydrogels as biomaterials. The molecular design of small-molecule peptides and their applications in bio-medicine are also discussed.

並列關鍵字

Hydrogel ； Hydrogelator ； Self-assembly ； Peptide ； Biomaterial