Jin Kui Yao Lue was an important classic book describing the endogenous miscellaneous diseases in traditional chinese medicine.In the book ,it had a systematic and completive discussion to Asthenic disease; its application to "chronic fatigue syndrome" is also desirable .This article would discuss Asthenic disease include pathogens, signs and symptoms from the point of five Zang-viscera ,and introducing chinese herbal medicine to the suggestion of healthy modulation and promotion.